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Antimicrobial Peptides for Use in Biosensing Applications
"Current pathogen detection systems lack the stability, sensitivity, and time-independent functionality required for real-time biosensing in the field. Antibodies exhibit specificity for pathogenic bacteria but lack the sensitivity to detect reduced pathogen levels and the stability needed for detection in harsh environments. We are investigating naturally occurring antimicrobial peptides (AMPs) for pathogen detection due to their intrinsic stability in harsh environments, ease of synthesis, and broad range of activity and affinity towards microorganisms, including gram-negative and gram-positive bacteria. The focus of our research is the tailoring of AMPs not for antimicrobial activity but for selective binding to target pathogenic bacteria. We envision these tailored peptides will replace existing molecular recognition elements in current pathogen detection platforms."
United States. Army Research, Development, and Engineering Command
Morin, K. M.; Soares, J. W.; Mello, C. M.
2004-12
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Capstone Document: Mass Fatality Management for Incidents Involving Weapons of Mass Destruction
"The intent of this document is to aid ME/Cs in establishing a uniform mass fatality management strategy that mutually supports and integrates key agencies in the response effort. The general principles and best practices for managing large numbers of fatalities are addressed. This document also directs the reader to those agencies and documents that have more detailed information on specific areas of fatality management. This document focuses on the following topics: the role of ME/Cs and how to manage a catastrophic event, how to mobilize local, State, and Federal resources by identifying requirements, the use of a basic mass fatality management strategy, identification of critical variables that influence the fatality management strategy, specifically when remains are chemically or biologically contaminated, the work of other agencies that have addressed various aspects of fatality management, current training opportunities for ME/Cs."
United States. Army Research, Development, and Engineering Command
2005-08
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Biological Incident Operations: a Guide for Law Enforcement
"This guide provides an overview of the problems faced by law enforcement that are associated with a biological terrorism incident and specific recommendations for recognizing, preventing, and managing these problems. The guide begins with a brief overview of key aspects of biological terrorism that must be considered throughout planning, training, and response. The guide goes on to address such issues as Incident Awareness, Information/Intelligence, Personal Protection, Incident Response, Incident Investigation, Tactical Operations, Incident Control, and the Mobilization of Assets."
United States. Army Research, Development, and Engineering Command
2004-09
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Distance Learning for Incident Command
Dan Belk of the Redstone Arsenal gives this presentation on available distance learning programs for incident command.
United States. Army Research, Development, and Engineering Command
Belk, Dan
2005-11-01
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Development of Nanofibrous Membranes towards Biological Sensing
"Homeland Security and the Veterinary Services Activity, Office Of The Surgeon General (VSA, OTSG) have identified food as potential instruments for covert acts of bioterrorism involving Chem/Bio agents. Therefore, VSA, OTSG has established the need to develop technologies that can be used in the presumptive screening of food to minimize the health effects on the warfighter. Currently, there are no deployable biological detection capabilities that are truly rapid when sample preparation is included in the detection process."
United States. Army Research, Development, and Engineering Command
Senecal, A. G.; Magnone, J. P.; Senecal, K. J. . . .
2004-12
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Survival of Viral Biowarfare Agents in Disinfected Waters
"Protecting civilian and military water supplies has received more attention since the United States began its war on terror in 2001. Both chlorine and bromine are used by branches of the U.S. military for disinfecting water supplies; however, limited data exists as to the effectiveness of these additives when used against viral biowarfare agents. The present study sought to evaluate the survival of selected viral biothreat agents in disinfected water. Disinfected water samples were spiked with vaccinia virus strain WR [Western Reserve] and Venezuelan equine encephalitis (VEE) virus strain TC-83 each separately to a final concentration of approximately 1�-10^6 PFU/mL [Plaque Forming Units per Milliliter], and survival was assessed by plaque assay. Both viruses were inactivated by 1 mg/L [Milligrams per Liter] free available chlorine (FAC) and 2mg/L total bromine within one hour. In conclusion, these results demonstrate that both chlorine and bromine are effective disinfectants against vaccinia virus and VEE strain TC-83 at the concentrations tested."
United States. Army Research, Development, and Engineering Command
Wade, Mary Margaret; Zulich, Alan W.; Chambers, Amanda E.
2010-07
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Army Research Laboratory S&T Campaign Plans 2015-2035
From the Introduction: "[E]ach of these S&T [science and technology] Campaigns is designed to explore, better understand, mature, and exploit S&T developments leading to Power Projection Superiority, Information Supremacy, Lethality & Protection Superiority, and Soldier Performance Augmentation that are essential to the future Army. This document defines each of ARL's [Army Research Laboratory's] S&T Campaign Plans and is an appendix to the Army Research Laboratory Technical Strategy (April 2014). It is intended to provide additional insight into the technical areas that ARL believes are critical to the Army's assured land power dominance into the deep future. Each S&T Campaign Plan provides a high-level overview of the campaign's technical landscape; a taxonomic breakdown of the campaign; descriptions of the technical areas constituting the campaign; and defines ARL's S&T Footprint in these areas including the laboratory's posture relative to the S&T area."
U.S. Army Research Laboratory; United States. Army Research, Development, and Engineering Command
2014-09
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Comparison of QSAR Based Thermo and Water Solvation Property Prediction Tools and Experimental Data for Selected Traditional Chemical Warfare Agents and Simulants
In the context of this report, QSAR stands for Quantitative Structure Activity Relationship. From the Abstract: "There is a need for rapid prediction of the physico-chemical properties of chemical warfare agents (CWAs) and toxic industrial chemicals (TICs) on environmentally relevant materials, personal protective equipment, and human tissue. It is the objective of this report to survey the reliability from several available in-silico tools for a set of physico-chemical properties that impact prediction of environmental fate of a set of traditional CWAs and simulants. The tools included EPI [Estimation Programs Interface] Suite, ACD [Advanced Chemistry Development ] Labs, ADF [Amsterdam Density Functional Code] COSMO-RS [COnductor like Screening MOdel for Realistic Solvents], ChemAxon's Marvin, and Vega. Of the predictive tools surveyed, EPI Suite and ACD Labs consistently had the highest accuracy for boiling point, vapor pressure. EPI Suite and ACD Labs gave reasonable results for octanol-water partitioning coefficient and water solubility for most compounds evaluated. For available measurements, ACD Labs, COSMO-RS, and Marvin were within two log units of the measured value. Arrangements of atoms outside the model training set accounted for much of the error between prediction and experiment. For molecular properties dependent on descriptors such as dipole moment, the effect of molecular symmetry most likely accounts for significant overestimation. The fragment based models."
Edgewood Chemical Biological Center; United States. Army Research, Development, and Engineering Command
Knox, Craig K.; Cabalo, Jerry Becker
2014-07
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Guidelines for Mass Casualty Decontamination During an HAZMAT/Weapon of Mass Destruction Incident: Volumes I and II
"In April 2009, the U.S. Army Edgewood Chemical Biological Center (ECBC) published a report, 'Guidelines for Mass Casualty Decontamination During a HAZMAT/Weapon of Mass Destruction Incident, Volumes I and II (ECBC-SP-024)' as an update to two previous reports; 'Guidelines for Mass Casualty Decontamination During a Terrorist Chemical Agent Incident (ECBC--TR-125)' and 'Guidelines for Cold Weather Mass Decontamination', which were both about 8 years old at the time. Due to recent international research and recommendations submitted by the Mass Casualty Decontamination Integrated Project Team (IPT), the U.S. Army Chemical Biological, Radiological and Nuclear School tasked ECBC to update ECBC-SP-024 for their continued refinement of decontamination doctrine. Accordingly, ECBC formed and led a team to update ECBC-SP-024. The focus of this study is decontamination of hazards (chemical, biological, radiological, unknown) and was updated with input from community responders, Army responders, DoD medical, and DoD chemical-biological technical expertise. This report will serve as the updated basis for doctrine and will be applicable to DoD and civilian response organizations as well."
United States. Army Research, Development, and Engineering Command; Edgewood Chemical Biological Center
Lake, William A.; Divarco, Stephen; Schulze, Peter . . .
2013-08
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Convoy Active Safety Technology - Information Brief [presentation]
These slides describe the dangers and technological safety measures related to convoy operations. From the text: "Convoy operations are inherently dangerous due to numerous threats on the battlefield while having limited defensive capability. Increased situational awareness and reduced fatigue can mitigate threats resulting in improved survivability and sustainment throughput."
United States. Army Research, Development, and Engineering Command; U.S. Army Tank-Automotive Research, Development, and Engineering Center
Schoenherr, Edward
2010-04
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