Risk Factors Associated with SARS-CoV-2 Breakthrough Infections in Fully mRNA-Vaccinated Individuals: Retrospective Analysis   [open pdf - 347KB]

From the Abstract: "COVID-19 [coronavirus disease 2019] messenger RNA [ribonucleic acid] (mRNA) vaccines have demonstrated efficacy and effectiveness in preventing symptomatic COVID-19, while being relatively safe in trial studies. However, vaccine breakthrough infections have been reported. [...] This study aims to identify risk factors associated with COVID-19 breakthrough infections among fully mRNA-vaccinated individuals. [...] We conducted a series of observational retrospective analyses using the electronic health records (EHRs) of the Columbia University Irving Medical Center/New York Presbyterian (CUIMC/NYP) up to September 21, 2021. New York City (NYC) adult residences with at least 1 polymerase chain reaction (PCR) record were included in this analysis. Poisson regression was performed to assess the association between the breakthrough infection rate in vaccinated individuals and multiple risk factors--including vaccine brand, demographics, and underlying conditions--while adjusting for calendar month, prior number of visits, and observational days in the EHR. [...] Although we found both mRNA vaccines were effective, Moderna/mRNA-1273 had a lower incidence rate of breakthrough infections. Immunocompromised and male individuals were among the highest risk groups experiencing breakthrough infections. Given the rapidly changing nature of the SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2] pandemic, continued monitoring and a generalizable analysis pipeline are warranted to inform quick updates on vaccine effectiveness in real time." This article was originally published on the Journal of Medical Internet Research (JMIR) Public Health and Surveillance website: [https://publichealth.jmir.org/2022/5/e35311].

Cong Liu, Junghwan Lee, Casey Ta, Ali Soroush, James R Rogers, Jae Hyun Kim, Karthik Natarajan, Jason Zucker, Yehoshua Perl, Chunhua Weng. Posted here with permission. Document is under a Creative Commons license and requires proper attribution and noncommercial use to be shared: [https://creativecommons.org/licenses/by/4.0/].
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JMIR Publications: https://jmirpublications.com/
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JMIR Public Health and Surveillance (2022), v.8 issue 5
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