Statin Use and COVID-19 Infectivity and Severity in South Korea: Two Population-Based Nationwide Cohort Studies   [open pdf - 593KB]

From the Introduction: "COVID-19 [coronavirus disease 2019] is caused by SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2], and started in Wuhan, China. The World Health Organization (WHO) declared COVID-19 a pandemic on March 12, 2020 [...]. In Korea, the first COVID-19 patient was diagnosed on January 20, 2020. During the period from January 1, 2020, to May 31, 2020, the number of daily confirmed COVID-19 cases was less than 2000 and the cumulative number of COVID-19 cases was 11,468 with 270 deaths [...]. During this pandemic phase, efficient strategies for triage and therapeutics are crucial due to the high number of patients with SARS-CoV-2 infection, and the relatively limited facilities and medical resources [...]. The effective treatment of patients with COVID-19 has still not been established. Previous studies have suggested potential therapeutic candidates, including antimalarial drugs [...], antivirals such as lopinavir and ritonavir in combination [...], remdesivir [...], previous bacillus Calmette-Guérin (BCG) vaccination [...], famotidine [...], and immunoglobulin-containing sera from convalescent patients with COVID-19 [...]. However, antimalarial drugs and the lopinavir-ritonavir combination proved ineffective in clinical trials [...], and previous studies on BCG vaccination, famotidine, and immunoglobulin-containing sera had small sample sizes and preliminary study designs [...]. Remdesivir improved clinical outcomes in patients with COVID-19, but it is not readily available[.]"

2021 Seung Won Lee, So Young Kim, Sung Yong Moon, In Kyung Yoo, Eun-Gyong Yoo, Gwang Hyeon Eom, Jae-Min Kim, Jae Il Shin, Myung Ho Jeong, Jee Myung Yang, Dong Keon Yon. Posted here with permission. Document is under a Creative Commons license and requires proper attribution and noncommercial use to be shared: [https://creativecommons.org/licenses/by/4.0/].
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JMIR Public Health Surveillance (October 8, 2021), v.7 issue 10
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