Navigating the World That COVID-19 Made: A Strategy for Revamping the Pandemic Research and Development Preparedness and Response Ecosystem   [open pdf - 0B]

From the Introduction: "Over the past several decades, governments and international agencies commissioned dozens of scenarios, blue ribbon reports, and multiday tabletop exercises that revealed the potential toll and trajectory of a major epidemic and the glaring need for a robust capacity for vaccine research and development (R&D) and response. Despite these warnings, adequate upgrades were not made to most national and international structures, and the COVID-19 [coronavirus disease 2019] pandemic revealed that a true, end-to-end R&D and response ecosystem--meaning, one that both produces and delivers needed vaccines to global populations in a rapid and equitable fashion--remains an elusive goal. The goals of this report are to: (1) identify the greatest opportunities and workable ideas for shortening the time to vaccine availability and (2) eliminate disparities in access in future pandemics by proposing ways to rework the architecture that supports the end-to-end vaccine R&D and response ecosystem. This report is comprised of 3 major sections. The first section defines what the pandemic vaccine R&D and response ecosystem is: a network of interacting actors and infrastructure involved in researching, developing, manufacturing, allocating, distributing, financing, and delivering vaccines against pandemic threats. It describes this ecosystem at the national and global levels and assesses its performance in the COVID-19 pandemic. The second section of this report identifies ways in which COVID-19 has changed government, industry, and institutional perceptions and priorities for the pandemic R&D and response ecosystem to confront to future threats. It considers the strategic implications of those changes for efforts to ensure the world is better prepared when the next pandemic threat emerges, as it inevitably will. The third section of this report assesses the major gaps and opportunities revealed along the value chain to the production of COVID-19 vaccines, including the sharing of genetic sequence data, viral specimens, and biological reference materials; prior research on platform technologies and pathogens with pandemic potential; establishment and scale up of manufacturing capacity; equitable distribution and access; and mobilization of financing and resources."

2021 The Johns Hopkins University
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Johns Hopkins Bloomberg School of Public Health Center for Health Security: https://www.centerforhealthsecurity.org/
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