ABSTRACT

Proximal Origin of SARS-CoV-2   [open pdf - 0B]

From the Document: "Since the first reports of novel pneumonia (COVID-19 [coronavirus disease 2019]) in Wuhan, Hubei province, China, there has been considerable discussion on the origin of the causative virus, SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2] (also referred to as HCoV-19 [human coronavirus 2019]). Infections with SARS-CoV-2 are now widespread, and as of 11 March 2020, 121,564 cases have been confirmed in more than 110 countries, with 4,373 deaths. SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV [severe acute respiratory syndrome-associated coronavirus], MERSCoV [Middle East respiratory syndrome coronavirus] and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus."

Author:
Publisher:
Date:
2020-03-17
Series:
Copyright:
Nature Publishing Group
Retrieved From:
Nature Medicine: https://www.nature.com/nm/
Media Type:
application/pdf
Source:
Nature Medicine (April 2020), v.26, p.450-452
URL:
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