Human Antibody Responses to SARS-CoViD-2 [video]   [open html - 0B]

From the Video Description: "Dr. Nussenzweig is the Zanvil A. Cohn and Ralph M. Steinman Professor at The Rockefeller University, New York, and a Howard Hughes Medical Institute Investigator. Nussenzweig's laboratory studies the molecular aspects of the immune system's innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2] coronavirus, among other viruses. Dr. Nussenzweig will speak about the development of antibody responses focusing on neutralizing antibody responses to SARS-CoViD-2 [sic]. Over a decade ago, the Nussenzweig laboratory developed methods for rapid antibody cloning from humans in order to understand humoral immune responses to pathogens beginning with HIV-1. These methods have been widely adapted by others facilitating antibody cloning for multiple human pathogens and their clinical development. At the start of the COVID-19 [coronavirus disease 2019] pandemic a group of 148 individuals that had recovered from SARS-CoV-2 infection were recruited to Rockefeller University to give blood for analysis. The lecture will summarize features of their humoral immune response in these individuals and their neutralizing properties in vitro and in animal models." The duration of this video is 1 hour, 4 minutes, and 9 seconds.

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