ABSTRACT

Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide   [open pdf - 1MB]

From the Abstract: "Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and higher mortality. Clinicians need to be more aggressive when treating obese, especially severely obese, patients with COVID-19 infection."

Author:
Publisher:
Date:
2020-07
Series:
Copyright:
2020 Mayo Foundation for Medical Education and Research. Posted here with permission. Documents are for personal use only and not for commercial profit.
Retrieved From:
National Center for Biotechnology Information: https://www.ncbi.nlm.nih.gov/
Format:
pdf
Media Type:
application/pdf
Source:
Mayo Clinic Proceedings (July, 2020), v.95 no.7, pp.1445-1453
URL:
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