RT-PCR Tests for SARS-COV-2 Processed at a Large Italian Hospital and False-Negative Results Among Confirmed COVID-19 Cases [open pdf - 250KB]
From the Document: "In Italy, the first autochthonous case of coronavirus disease 2019 (COVID-19) was detected on February 21, 2020. By mid April 2020, >15,000 persons had been infected in the country and >20,000 had died. More than 1 million upper respiratory specimens were collected through nasopharyngeal or oropharyngeal swabs2 for infection confirmation or screening purposes. The proportion of the population with confirmed infection varies across the 20 Italian regions, as does the number of swabs collected per population unit. Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) is used to test for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in the specimens collected through swabs, as recommended by the World Health Organization for clinical management and outbreak control purposes. It is currently the gold standard for the etiological diagnosis of SARS-CoV-2 infection."
2020 Society for Healthcare Epidemiology of America. Posted here with permission. Document is under a Creative Commons license and requires proper attribution and noncommercial use to be shared: [https://creativecommons.org/licenses/by/4.0/]
Cambridge University Press: https://www.cambridge.org/
Infection Control & Hospital Epidemiology (2020), 1-2