Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas [video] [open html - 0B]
From the Description: "The COVID-19 [coronavirus disease 2019] pandemic, caused by the novel coronavirus SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2], creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Single-cell analysis of healthy- and SARS-CoV-2-infected tissues offers a unique lens to identify these mechanisms. In an international integrated analysis of the Human Cell Atlas Lung Biological Network--which spans more than 100 single-cell and single-nucleus RNA-Seq [ribonucleic acid sequencing] datasets previously collected from healthy tissues and includes many previously unpublished studies--we identified the cell types throughout the body most likely to be susceptible to viral entry. In line with epidemiological observations, we also identified increased expression of key mediators of SARS-CoV-2 cellular entry associated with increasing age, male gender, and smoking." The length of this video is 1:01:21.
National Institutes of Health: https://www.nih.gov/