Recommendations for Incentivizing the Development of Vaccines, Diagnostics, and Therapeutics to Combat Antibiotic-Resistance   [open pdf - 5MB]

"The spread of antimicrobial resistance (AMR) is one of the most pressing public health problems facing the globe today. World leaders have recently acknowledged the growing threat of AMR; for example, the United Nations held a high-level meeting on AMR in September 2 016, and the Group of 20 (G20) released a declaration on combatting AMR in July 2017. Without interventions to curb the spread of AMR, it has been projected that by 2050, resistant infections will kill more people worldwide than cancer and cause global economic damage on par with the financial crisis of 2008. T he Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was established in 2015 in consultation with the Secretaries of Defense, Agriculture, and Health and Human Services as part of a coordinated effort by the U.S. government to respond to this threat. In its 2015 report, Initial Assessments of the National Action Plan for Combating Antibiotic-Resistant Bacteria, PACCARB suggested that the current economic model is insufficient to ensure the availability of products and resources to fight AMR. Consequently, the PACCARB agreed to propose recommendations for incentivizing the development of new products to reduce the spread of AMR for both humans and animals."

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