Pathomics: Final Report   [open pdf - 6MB]

"Pathomics is a research project to explore the feasibility for developing biosignatures for early infectious disease detection in humans, particularly those that represent a threat from bioterrorism. Our goal is to use a science-based approach to better understand the underlying molecular basis of disease and to find sensitive, robust, and specific combinations of biological molecules (biosignatures) in the host that will indicate the presence of developing infection prior to overt symptoms (pre-syndromic). The ultimate goal is develop a national surveillance system for monitoring for the release and managing the consequences of a biothreat agent or an emerging disease. Developing the science for a more comprehensive understanding of the molecular basis of infectious disease and the development of biosignature-based diagnostics could help detect both emerging and engineered treats to humans. […]It has been well-described that the health and societal consequences of the release of a bioterror agent or the emergence of a new natural pathogen could be severe […] Whether through an act of terrorism or nature, infectious disease epidemics are potentially the most lethal and certainly most insidious of natural disasters […] Bubonic plague (Yersinia pestis) was responsible for a staggering 25 million deaths (roughly a quarter of the entire population) in 14th century Europe. Although less deadly than the plague, smallpox had a tremendous impact on the development of Western civilization […] In 1918 a global pandemic caused by a particularly virulent strain of influenza killed more than 40 million people in the span of 8 months and hospitalized more individuals than the total number of those wounded in World War I."

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Lawrence Livermore National Laboratory: https://www.llnl.gov/
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