"President Bush has made strengthening the nation's defenses against biological weapons a critical national priority from the outset of the administration - investing over $10 billion since 2001. While significant progress has been made to protect America, President Bush instructed Federal departments and agencies to review their efforts and find new and better ways to secure America from bioattacks. The result of this review is Biodefense for the 21st Century, a presidential directive that provides a comprehensive framework for our nation's biodefense. Biodefense for the 21st Century builds on past accomplishments, specifies roles and responsibilities, and integrates the programs and efforts of various communities - national security, medical, public health, intelligence, diplomatic, agricultural and law enforcement - into a sustained and focused national effort against biological weapons threats. Other keywords and phrases in this review are: threat awareness, prevention and protection, surveillance and detection, and response and recovery."