In the next decade, the United States, as the only world superpower, will face a strategic environment characterized by significant uncertainty and ambiguity. Inherent in this environment will be new, asymmetric threats to our national security, both at home and abroad. Transnational terrorist and criminal organizations, using the latest technology, will gain increased access and ability to employ weapons of mass destruction (WMD) within our borders. The Federal Response Plan is an over-complicated attempt at coordinating numerous federal departments and agencies for effective response to domestic crisis situations. Early warning and preemption would certainly be the best response to WMD attack, but bureaucratic rivalry within the U.S. Intelligence Community hinders the focus necessary to consistently achieve that goal. This paper examines and recommends changes to the federal domestic crisis response apparatus, in a search for greater efficiency and unity of effort in preparing the nation for WMD attack.