"The use of prescription antiviral drugs to treat and prevent infection will be an important component of a pandemic influenza response. While current antiviral drug use strategies and publicly maintained stockpiles are targeted primarily for treatment of persons with pandemic illness, expanded antiviral drug production has allowed additional strategies to be considered. An interagency working group, with input from representatives of State, local and tribal public health agencies, considered scientific issues, ethics and values, and perspectives of stakeholders in developing draft guidance on antiviral use strategies and stockpiling. The antiviral drug use guidance in this document replaces the recommendations developed in 2005 which are published as part of the Department of Health and Human Service's (HHS's) pandemic influenza plan. As guidance, this document does not create a requirement; rather, it defines a prudent strategy for antiviral drug stockpiling and use that can contribute to a more effective pandemic response. The guidance on antiviral use is based on the national pandemic response goals of slowing the spread of pandemic disease, reducing impacts on health, and minimizing societal and economic disruption."