Clinical and Epidemiologic Principles of Anthrax   [open pdf - 68KB]

Anthrax, in the minds of most military and counterterrorism planners, represents the single greatest biological warfare threat. A World Health Organization report estimated that 3 days after the release of 50 kg of anthrax spores along a 2-km line upwind of a city of 500,000 population, 125,000 infections would occur, producing 95,000 deaths. This number represents far more deaths than predicted in any other scenario of agent release. Moreover, it has been estimated that an aerial spray of anthrax along a 100-km line under ideal meteorologic conditions could produce 50% lethality rates as far as 160 km downwind. Finally, the United States chose to include anthrax in the now-defunct offensive biological weapons program of the 1950s, and the Soviet Union and Iraq also admitted to possessing anthrax weapons. An accident at a Soviet military compound in Sverdlovsk in 1979 resulted in at least 66 deaths due to inhalational anthrax, an inadvertent demonstration of the viability of this weapon. The epidemiology of this inadvertent release was unusual and unexpected. None of the persons affected were children. Whether this is due to differences in susceptibility between children and adults or purely to epidemiologic factors (children may not have been outdoors at the time of release) is unclear. In summary, even though anthrax may be among the most viable of biological weapons, it is also a weapon for which a licensed vaccine and good antimicrobial therapy and postexposure prophylaxis exist. Given the relatively short incubation period, and rapid progression of disease, however, identification of the exposed population within 24 to 48 hours and employment of therapeutic and prophylactic strategies are likely to present a challenge. Good intelligence regarding the capabilities of terrorist groups, as well as heightened awareness of the threat on the part of clinicians, first responders, and public health personnel remains a cornerstone of bioterrorism defense.

Public Domain
Retrieved From:
Centers for Disease Control: http://www.cdc.gov/
Media Type:
Emerging Infectious Diseases (July-August 1999), v.5 no.4, p. 552-555
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