This pamphlet provides information to familiarize commanders with the Chemical and Biological (CB) defense program. The significant changes in Air Force missions, roles, and manpower have resulted in an information gap in the area of CB defense. In conjunction with providing updated CB defense information; this document can be used as a tool for evaluating CB defense program readiness. It focuses on the principles of CB defense and an insight to CB vulnerability analysis. The pamphlet supports AFI 32-4001, Disaster Preparedness Planning and Operations, and the USAF CB Defense Concept of Operations.