AFRRI's Gamma-Ray, X-Ray, and Fission-Neutron Calibration Curves for the Lymphocyte Dicentric Assay: Application of a Metaphase Finder System [open pdf - 308KB]
This paper reports dose-response or calibration curves of measured dicentric yields following exposure to 250-kVp x rays, 60Co gamma rays, and fission neutrons, whose radiation qualities have been measured at AFRRI (Bethesda, MD) in terms of their microdosimetric parameters. In addition, we compare these dose response calibration curves with similar studies from other laboratories. Estimating radiation dose by chromosome aberration analysis requires time-demanding and labor-intensive scoring by expert cytogeneticists. Our attempt to decrease cytogenetic scoring time in biodosimetric assessment for radiation accidents is addressed by the use of satellite scoring stations used in conjunction with an automated metaphase finder.
AFRRI Special Publication 02-1