"This report is an update to the previous reports to Congress that were provided in June and December 2006 and in June 2007. This report covers all activities from December 2005 to December 2007. The report covers the pandemic influenza funding provided in both the December 2005 emergency supplemental appropriations bill (PL 109-148) and the June 2006 emergency supplemental appropriations bill (PL 109-234). In August 2005, animal outbreaks of highly pathogenic H5Nl had been reported in twelve countries around the world with 112 total human cases confirmed in four of those countries. Just over two years later in December 2007, the number of countries confirming animal outbreaks has jumped to 61, with 346 total human cases confirmed in fourteen of those countries. While the majority of human cases to date can be attributed to exposure to infected poultry, and sustained human-to-human transmission has not been observed, the human infections have been severe. Overall, 62 percent of human cases have been fatal. History shows that the mortality rate of a human pandemic virus is not likely to be this high. However, even a two percent case-fatality rate, as was seen in the 1918 pandemic, would constitute a public health catastrophe. Once a pandemic begins, time will be a critical factor in our ability to accomplish the necessary production and delivery of vaccines and other medical countermeasures required to mitigate the pandemic."
Medical Countermeasures.gov: https://www.medicalcountermeasures.gov/default.aspx